局部热疗治疗 Darier 病广泛性病毒性疣：病例报告及文献复习。
Local hyperthermia treatment of extensive viral warts in Darier disease: a case report and literature review.
机构信息
Department of Dermatology, Hospital of China Medical University, Shenyang, China.
出版信息
Int J Hyperthermia. 2012;28(5):451-5. doi: 10.3109/02656736.2012.677929. Epub 2012 Jun 12.
BACKGROUND
Darier disease is an autosomal dominant hereditary skin disease that is susceptible to secondary bacterial or fungal infections, but rarely to human papillomavirus (HPV) infections. Multiple or extensive warts from HPV remain a therapeutic challenge, but local hyperthermia is effective. We treated a patient with Darier disease who had superimposed warts in the genital and neck regions.
MATERIALS AND METHODS
The patient was treated with tolerable local hyperthermia with infrared light from a halogen lamp (surface temperature, 40°C) to a single target lesion on the genitalia (30 min daily) for 3 consecutive days.
RESULTS
Within 2 weeks, the target lesion cleared and synchronous regression of untreated lesions on the neck was observed.
CONCLUSIONS
In Darier disease, local hyperthermia treatment of HPV warts in 1 region was effective in treating multiple lesions, including lesions at a remote site, possibly by promoting an immune response against HPV.
背景
Darier 病是一种常染色体显性遗传性皮肤病，易继发细菌或真菌感染，但很少发生人乳头瘤病毒（HPV）感染。HPV 导致的多发性或广泛性疣仍然是一个治疗挑战，但局部热疗是有效的。我们治疗了一位 Darier 病患者，他的生殖器和颈部区域同时出现了疣。
材料和方法
我们采用可耐受的局部热疗，使用卤素灯的红外线（表面温度 40°C）对生殖器的单个靶病变进行治疗（每天 30 分钟），连续 3 天。
结果
2 周内，靶病变消退，同时观察到颈部未治疗病变的同步消退。
结论
在 Darier 病中，对 1 个区域的 HPV 疣进行局部热疗治疗有效，可治疗多个病变，包括远处部位的病变，可能是通过促进针对 HPV 的免疫反应。
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