Abdalla Hussein M
Biochemistry Department, Faculty of Pharmacy, October 6 University, October 6 City, Egypt.
Malays J Nutr. 2010 Dec;16(3):419-29. Epub 2010 Dec 15.
Purslane extract in the form of ethanolic formulation is rich in polyphenols, flavonoids and anthocyanin, w-3 fatty acids and melatonin. The present study was designed to investigate the anti-obesity and anti-diabetic effects of purslane using obese diabetic rats. The rats received either regular diet, high-fat diet or high-fat diet with additional purslane (150 and 300 mg/kg body weight) for 8 weeks. Purslane, co-administered with a high fat diet, significantly inhibited body weight gain, blood glucose, triglyceride, total cholesterol, LDL-C, HDL-C, free fatty acids and the atherogenic index levels in a dose dependent manner. Purslane-treated rats at doses of 150 and 300 mg/kg body weight improved the insulin resistance index when compared to high fat diet control. In conclusion, purslane ethanolic extract showed effects indicative of potential anti-obesity and anti-diabetic actions in rats fed a high fat obesity-induced diet.
乙醇制剂形式的马齿苋提取物富含多酚、黄酮类化合物、花青素、ω-3脂肪酸和褪黑素。本研究旨在使用肥胖糖尿病大鼠研究马齿苋的抗肥胖和抗糖尿病作用。大鼠接受常规饮食、高脂饮食或高脂饮食加额外的马齿苋（150和300毫克/千克体重），持续8周。与高脂饮食共同给药时，马齿苋以剂量依赖性方式显著抑制体重增加、血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、游离脂肪酸和动脉粥样硬化指数水平。与高脂饮食对照组相比，体重剂量为150和300毫克/千克的马齿苋处理大鼠改善了胰岛素抵抗指数。总之，马齿苋乙醇提取物在喂食高脂肪诱导肥胖饮食的大鼠中显示出潜在的抗肥胖和抗糖尿病作用。
