Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Sci Rep. 2016 Dec 5;6:37819. doi: 10.1038/srep37819.
The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) purslane seeds (PS), aerobic training+purslane seeds (AT + PS). The training program and purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of purslane seed were identified and quantified by GC-MS. Blood samples were withdrawn via venipuncture to examine blood glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, triglycerides (TG), creatinine, urea, uric acid, NF-κB, GLP1, GLP1R, TIMP-1, MMP2, MMP9, CRP, CST3, and CTSS expressions. Blood glucose, LDL, cholesterol, TG, creatinine, urea, and uric acid levels in the (P), (AT), and (AT + PS) groups were significantly decreased compared to the pre-experimental levels or the placebo group, while HDL, significantly increased. Furthermore, the protein and mRNA levels of NF-κB, TIMP-1, MMP2 &9, CRP, CST3, and CTSS in the (P), (AT), (AT + PS) significantly decreased compared to pre-experimental or the placebo group, while level of GLP1 and GLP1-R increased drastically. Findings suggest that purslane seed consumption alongside exercising could improve atherosclerosis plaque biomarkers through synergistically mechanisms in T2D.
本研究旨在探讨马齿笕籽摄入和有氧运动对 2 型糖尿病女性动脉粥样硬化斑块生物标志物的影响。196 名 2 型糖尿病女性被分为：（1）安慰剂组（PL），（2）有氧运动+安慰剂组（AT+PL），（3）马齿笕籽组（PS），有氧运动+马齿笕籽组（AT+PS）。训练计划和马齿笕籽摄入（午餐 2.5 克，晚餐 5 克）持续进行 16 周。通过 GC-MS 鉴定和定量马齿笕籽的成分。通过静脉穿刺抽取血液样本，以检测血糖、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、胆固醇、甘油三酯（TG）、肌酐、尿素、尿酸、NF-κB、GLP1、GLP1R、TIMP-1、MMP2、MMP9、CRP、CST3 和 CTSS 的表达。与实验前或安慰剂组相比，（P）、（AT）和（AT+PS）组的血糖、LDL、胆固醇、TG、肌酐、尿素和尿酸水平显著降低，而 HDL 水平显著升高。此外，与实验前或安慰剂组相比，（P）、（AT）、（AT+PS）组的 NF-κB、TIMP-1、MMP2&MMP9、CRP、CST3 和 CTSS 的蛋白和 mRNA 水平显著降低，而 GLP1 和 GLP1-R 水平显著升高。研究结果表明，马齿笕籽摄入结合运动可以通过协同机制改善 2 型糖尿病患者的动脉粥样硬化斑块生物标志物。
