自噬在肾功能、疾病和衰老中的新作用。
Emerging role of autophagy in kidney function, diseases and aging.
机构信息
Renal Division, University Hospital Freiburg; Freiburg, Germany.
出版信息
Autophagy. 2012 Jul 1;8(7):1009-31. doi: 10.4161/auto.19821. Epub 2012 Jun 13.
Abstract
Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.
摘要
自噬是一种高度保守的过程，可降解细胞内的长寿蛋白质和细胞器。越来越多的证据表明，自噬在肾脏维持、疾病和衰老中起着关键作用。缺血、毒性、免疫和氧化应激可导致肾上皮细胞自噬的诱导，从而改变各种肾脏疾病的进程。本综述总结了自噬在肾脏生理学和疾病中的作用的最新认识，暗示通过改变自噬来治疗特定肾脏疾病的可能新的干预策略。
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本文引用的文献
1
Autophagy: Many paths to the same end.自噬：殊途同归。
Mol Cell Biochem. 2004 Aug;263(1):55-72. doi: 10.1023/B:MCBI.0000041848.57020.57.
2
Guidelines for the use and interpretation of assays for monitoring autophagy.自噬监测分析方法的使用和解读指南
Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496.
3
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.自噬在维持肾脏小管、衰老和缺血再灌注损伤中发挥着关键作用。
Autophagy. 2012 May 1;8(5):826-37. doi: 10.4161/auto.19419.
4
Autophagy guards against cisplatin-induced acute kidney injury.自噬可预防顺铂诱导的急性肾损伤。
Am J Pathol. 2012 Feb;180(2):517-25. doi: 10.1016/j.ajpath.2011.11.001.
5
Prorenin receptor is essential for podocyte autophagy and survival.原朊素受体对于足细胞自噬和存活是必需的。
J Am Soc Nephrol. 2011 Dec;22(12):2193-202. doi: 10.1681/ASN.2011020200. Epub 2011 Oct 27.
6
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.AMP 依赖的激酶/雷帕霉素哺乳动物靶蛋白复合物 1 信号在 T 细胞急性淋巴细胞白血病中的作用：治疗意义。
Leukemia. 2012 Jan;26(1):91-100. doi: 10.1038/leu.2011.269. Epub 2011 Oct 4.
7
mTOR signaling in disease.mTOR 信号通路与疾病。
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8
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9
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10
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.mTOR 复合物 1 调节脂滴包被蛋白 1 的定位以控制 SREBP 通路。
Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.
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