Carlson R M
University of Minnesota Duluth 55812.
Environ Health Perspect. 1990 Jul;87:227-32. doi: 10.1289/ehp.9087227.
Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. With the observation of site specificity in mutagenic events. Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. Methods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships.
亲电特性与外部试剂与生物大分子中电子密度中心相互作用并导致正常活性中断或改变的能力相关。随着诱变事件中位点特异性的观察，皮尔逊的硬/软酸碱理论（HSAB）作为一种有用的概念被提出，用于在缺乏该过程详细直接知识的情况下关联化学观察结果。作为反应物的碳亲电试剂（例如碳正离子特性）的评估方法被综述为可用于建立定量构效关系的潜在物理参数。
