Weiss Douglas J
University of Minnesota, MN, USA.
Compend Contin Educ Vet. 2012 Jun;34(6):E2.
Many therapeutic drugs have been associated with hematologic adverse drug events (ADEs) in animals. Some drugs, notably chemotherapeutic agents and oxidant compounds, cause dose-dependent bone marrow suppression, while others induce idiosyncratic ADEs. Major mechanisms associated with ADEs include immune- or oxidant-mediated destruction of blood cells and toxic bone marrow injury. General classes of drugs that can cause idiosyncratic ADEs include estrogenic compounds, NSAIDs, antibiotics, antifungals, antithyroid drugs, anticonvulsants, antiparasitics, and cardiac drugs. ADEs associated with chemotherapeutic agents, phenylbutazone, phenobarbital, propylthiouracil (in cats), methimazole (in cats), and azathioprine occur frequently enough to warrant performing periodic complete blood counts during the course of treatment.
许多治疗药物与动物血液学不良药物事件（ADEs）有关。一些药物，特别是化疗药物和氧化化合物，会导致剂量依赖性骨髓抑制，而其他药物则会引发特异质性ADEs。与ADEs相关的主要机制包括免疫或氧化介导的血细胞破坏以及毒性骨髓损伤。可导致特异质性ADEs的一般药物类别包括雌激素化合物、非甾体抗炎药、抗生素、抗真菌药、抗甲状腺药、抗惊厥药、抗寄生虫药和心脏药物。与化疗药物、保泰松、苯巴比妥、丙硫氧嘧啶（猫用）、甲巯咪唑（猫用）和硫唑嘌呤相关的ADEs发生频率足够高，因此在治疗过程中需要定期进行全血细胞计数。
