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一种富含岩藻黄质的天然褐藻提取物（Ascophyllum nodosum）的抗氧化、抗炎和抗衰老活性。

Antioxidant, anti-inflammatory, and anti-senescence activities of a phlorotannin-rich natural extract from brown seaweed Ascophyllum nodosum.

机构信息

Yslab, 2 rue Félix Le Dantec, 29000 Quimper, France.

出版信息

Appl Biochem Biotechnol. 2012 Aug;167(8):2234-40. doi: 10.1007/s12010-012-9761-1. Epub 2012 Jun 13.

DOI:10.1007/s12010-012-9761-1
PMID:22692848
Abstract

Aging at the cellular level is characterized by oxidative stress, inflammation, and cell senescence. An extract of the brown seaweed Ascophyllum nodosum rich in phlorotannins has been studied for its inhibitory activity against oxidative stress, inflammation, and senescence. A. nodosum extract at 0.2 % prevented tBHP-induced reactive oxygen species production (evaluated using the H2DCF-DA test in cytofluorometry) in epithelial cells and LPS-induced TNF-α and IL-6 release (evaluated using ELISA technique) in macrophages. A. nodosum extract also increased nuclear SIRT1 activity in epithelial cells. Altogether, these beneficial cellular effects of phlorotannin-rich A. nodosum extract could be used in topical therapeutic formulations against aging.

摘要

细胞水平的衰老表现为氧化应激、炎症和细胞衰老。一种富含岩藻黄质的褐藻裙带菜提取物因其对氧化应激、炎症和衰老的抑制活性而受到研究。0.2%的裙带菜提取物可预防 tBHP 诱导的上皮细胞活性氧产生（通过细胞荧光法用 H2DCF-DA 试验评估）和 LPS 诱导的巨噬细胞 TNF-α 和 IL-6 释放（通过 ELISA 技术评估）。裙带菜提取物还增加了上皮细胞中的核 SIRT1 活性。总之，这种富含岩藻黄质的裙带菜提取物对细胞的有益作用可用于针对衰老的局部治疗制剂。

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