Muñoz-Quintana Marina, Padrón-Sanz Carolina, Dolbeth Marina, Arenas Francisco, Vasconcelos Vitor, Lopes Graciliana
Faculty of Veterinary and Experimental Sciences, Catholic University of Valencia "San Vicente Mártir", Guillem de Castro 94, 46001 Valencia, Spain.
Translational Research Center San Alberto Magno (CITSAM), Catholic University of Valencia "San Vicente Mártir", C/Quevedo, 2, 46001 Valencia, Spain.
Mar Drugs. 2024 Dec 4;22(12):548. doi: 10.3390/md22120548.
The natural products industry is gaining increasing interest, not only due to modern lifestyles becoming more aware of environmental and sustainability issues but also because of the loss of efficacy and undesirable side effects of synthetic ingredients. This pioneering study provides a comprehensive comparison between extracts obtained from wild and commercial samples of Linnaeus, highlighting their multifaceted benefits in cosmetic applications. The antiaging potential of acetone (70 and 90%) and ethanol 60% extracts from wild and commercial samples of , focusing on their application in cosmetics, was explored. The extracts were chemically characterized, their carotenoid profiles being established by HPLC, and the total phenolic content and phlorotannins by spectrophotometry. The extracts were evaluated for their antioxidant potential against the physiologic free radicals superoxide anion radical (O) and nitric oxide (NO), for their ability to inhibit the enzymes hyaluronidase and tyrosinase, and for their anti-inflammatory potential in the macrophage cell model RAW 264.7. The acetone 70% extract of wild was the richest in fucoxanthin, which accounted for more than 67% of the total pigments identified, followed by the acetone 90% extract of the same sample, where both fucoxanthin and pheophytin- represented 40% of the total pigments. The same behavior was observed for phenolic compounds, with the ethanol 60% presenting the lowest values. A chemical correlation could be established between the chemical composition and the biological activities, with acetone extracts from the wild , richer in fucoxanthin and phlorotannins, standing out as natural ingredients with anti-aging potential. Acetone 90% can be highlighted as the most effective extraction solvent, their extracts presenting the highest radicals scavenging capacity, ability to inhibit tyrosinase to a greater extent than the commercial ingredient kojic acid, and potential to slow down the inflammatory process.
天然产物行业正日益受到关注，这不仅是因为现代生活方式使人们更加关注环境和可持续性问题，还因为合成成分的功效丧失和不良副作用。这项开创性研究对从野生和商业样本中提取的提取物进行了全面比较，突出了它们在化妆品应用中的多方面益处。探索了野生和商业样本中丙酮（70%和90%）和乙醇60%提取物的抗衰老潜力，重点关注它们在化妆品中的应用。对提取物进行了化学表征，通过高效液相色谱法确定了它们的类胡萝卜素谱，并通过分光光度法测定了总酚含量和褐藻多酚。评估了提取物对生理自由基超氧阴离子自由基（O）和一氧化氮（NO）的抗氧化潜力、抑制透明质酸酶和酪氨酸酶的能力以及在巨噬细胞模型RAW 264.7中的抗炎潜力。野生样本的70%丙酮提取物中岩藻黄质含量最高，占鉴定出的总色素的67%以上，其次是同一样本的90%丙酮提取物，其中岩藻黄质和脱镁叶绿素占总色素的40%。酚类化合物也观察到相同的情况，60%乙醇提取物的值最低。化学成分与生物活性之间可以建立化学相关性，野生样本的丙酮提取物富含岩藻黄质和褐藻多酚，作为具有抗衰老潜力的天然成分脱颖而出。90%丙酮可被视为最有效的提取溶剂，其提取物具有最高的自由基清除能力，抑制酪氨酸酶的能力比商业成分曲酸更强，并且有减缓炎症过程的潜力。
