Castro-González Carlos, Ledesma-Carbayo María J, Peyriéras Nadine, Santos Andrés
Biomedical Image Technologies, ETSIT, Universidad Politécnica de Madrid, Spain and Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN), Spain.
Birth Defects Res C Embryo Today. 2012 Jun;96(2):109-20. doi: 10.1002/bdrc.21012.
Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms.
动物发育的数字图谱提供了形态发生的定量描述，为过程建模开辟了道路。原型图谱提供了一个数据整合框架，可从具有表型变异性的个体群体中收集信息。进一步理论重建的相关信息包括细胞行为和基因表达的时空测量。后者以及原型模型中的数据整合依赖于图像处理策略。开发整合和分析生物多维数据的工具对于评估化学毒性或进行药物临床前测试非常重要。本文概述了组装这些原型的一些最突出的努力，根据显著标准对它们进行分类，并讨论了该领域的关键问题以及在模式生物中重建多尺度动力学面临的未来挑战。
