新型香豆素衍生物功能化钌（II）配合物的合成、基于能量转移的酯酶传感、细胞毒性及成像研究。
New ruthenium(II) complexes functionalized with coumarin derivatives: synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies.
机构信息
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China.
出版信息
Chemistry. 2012 Jul 9;18(28):8724-30. doi: 10.1002/chem.201103025. Epub 2012 Jun 12.
Two new bichromophoric ruthenium(II) complexes, Ru(bpy)(2)(bpy-CM)(2) and Ru(bpy)(2)(bpy-CM343)(2) (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated.
两个新的双发色钌（II）配合物，Ru(bpy)(2)(bpy-CM)(2) 和 Ru(bpy)(2)(bpy-CM343)(2)（bpy=2,2'-联吡啶，CM=香豆素），具有附加的香豆素配体，已被设计和合成。通过使用紫外/可见和发光光谱方法研究了配合物对酯酶的基于能量转移的传感。还研究了其中一个配合物的细胞毒性和细胞摄取。
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