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金花茶花朵中一种新的酰化黄酮糖苷及其对人淋巴瘤U937细胞凋亡诱导的作用。

A new acylated flavonoid glycoside from the flowers of Camellia nitidissima and its effect on the induction of apoptosis in human lymphoma U937 cells.

作者信息

Peng Xiao, Yu Da-Yong, Feng Bao-Min, Wang Yong-Qi, Shi Li-Ying

机构信息

Institute of Materia Medica, Dalian University, Dalian 116622, China.

出版信息

J Asian Nat Prod Res. 2012;14(8):799-804. doi: 10.1080/10286020.2012.691475. Epub 2012 Jun 14.

Abstract

From the EtOH extract of the flowers of Camellia nitidissima Chi, a new acylated flavonoid glycoside, quercetin 7-O-(6"-O-E-caffeoyl)-β-D-glucopyranoside (1), has been isolated, together with three known flavonoids: quercetin (2), quercetin 3-O-β-D-glucopyranoside (3), and quercetin 7-O-β-D-glucopyranoside (4). Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was shown to inhibit proliferation and to induce apoptosis of human lymphoma U937 cells.

摘要

从金花茶花朵的乙醇提取物中,分离出一种新的酰化黄酮糖苷,槲皮素7 - O -(6″ - O - E - 咖啡酰基)-β - D - 吡喃葡萄糖苷(1),以及三种已知的黄酮类化合物:槲皮素(2)、槲皮素3 - O - β - D - 吡喃葡萄糖苷(3)和槲皮素7 - O - β - D - 吡喃葡萄糖苷(4)。通过光谱分析确定了它们的结构。化合物1被证明可抑制人淋巴瘤U937细胞的增殖并诱导其凋亡。

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