John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
Ocul Immunol Inflamm. 2012 Aug;20(4):266-72. doi: 10.3109/09273948.2012.670359. Epub 2012 Jun 13.
To describe two cases of bilateral acute iris transillumination following systemic administration of moxifloxacin and review the literature.
Review of clinical records, and review of the literature using the PubMed database.
A 75 year-old man and 33 year-old woman presented with bilateral conjunctival injection, photophobia, and atonic, distorted pupils. The symptoms began acutely following a respiratory illness, for which both were treated with moxifloxacin. Both patients demonstrated profound iris transillumination, sectoral posterior bowing of the iris, corneal endothelial pigment dusting, and trabecular meshwork hyperpigmentation. One patient had a cotton-wool spot. A literature review identified 59 previous reports in 5 publications, including 17 patients with no antecedent fluoroquinolone use.
Increased awareness of this recently described clinical entity should lead to a decrease in unnecessary diagnostic evaluations. It is currently unclear whether this disease represents an adverse effect of fluoroquinolone use or a sequela of a systemic illness.
描述两例全身应用莫西沙星后双侧急性虹膜光透射，并复习文献。
回顾临床记录，并使用 PubMed 数据库进行文献复习。
一名 75 岁男性和一名 33 岁女性出现双侧结膜充血、畏光和无张力、变形的瞳孔。症状在呼吸道疾病后急性发作，两人均接受莫西沙星治疗。两名患者均表现出明显的虹膜光透射、虹膜后扇形弯曲、角膜内皮色素尘状、小梁网过度色素沉着。一名患者出现棉絮斑。文献复习在 5 篇文献中确定了 59 例先前的报告，包括 17 例无氟喹诺酮使用史的患者。
提高对这种最近描述的临床实体的认识，应有助于减少不必要的诊断评估。目前尚不清楚这种疾病是氟喹诺酮类药物使用的不良反应，还是全身疾病的后遗症。
