Het Oogziekenhuis Rotterdam, Rotterdam Eye Hospital, Schiedamse Vest 180, Rotterdam, The Netherlands.
Eye (Lond). 2009 Dec;23(12):2260-2. doi: 10.1038/eye.2009.234.
To report a newly recognized adverse effect of oral moxifloxacin.
Observational case reports.
Five patients who used oral moxifloxacin therapy.
In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.
Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.
报告口服莫西沙星的一种新的不良反应。
观察性病例报告。
5 名使用口服莫西沙星治疗的患者。
在 5 名患者中，在口服莫西沙星治疗后出现了虹膜炎样发作，随后出现畏光。在裂隙灯检查下，患者表现出几乎完全的虹膜透照，不受限于一个扇区，瞳孔持续散大，对光无反应，无近反射。对其中 1 名患者进行了 3 年的随访，发现症状无变化。只有在 1 名有前葡萄膜炎病史的患者中，前房穿刺术检测到单纯疱疹基因组呈阳性。只有在使用莫西沙星后，她才持续出现畏光。
虹膜透照和括约肌麻痹是口服莫西沙星治疗的一种新的不良反应。
