Hong Xiao-Xiao, Luo Jian-Guang, Kong Ling-Yi
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
J Asian Nat Prod Res. 2012;14(8):769-75. doi: 10.1080/10286020.2012.691096. Epub 2012 Jun 14.
Two rare new chlorophenyl glycosides, 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (1) and 4-chlorol-5-hydroxyl-3-methyl-phenol 1-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2), along with three known compounds (3-5) were isolated from the bulbs of Lilium brownii var. viridulum. The structures of the new compounds were elucidated on the basis of spectroscopic and chemical methods. All the compounds exhibited weak inhibition of NO production in LPS-stimulated RAW 264.7 cells.
从百合的鳞茎中分离出两种罕见的新氯苯基糖苷，即2,4,6-三氯-3-甲基-5-甲氧基苯酚1-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖苷（1）和4-氯-5-羟基-3-甲基苯酚1-O-α-L-鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷（2），以及三种已知化合物（3-5）。通过光谱和化学方法阐明了新化合物的结构。所有化合物在脂多糖刺激的RAW 264.7细胞中均表现出对一氧化氮产生的微弱抑制作用。
