State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Chem Biodivers. 2021 Oct;18(10):e2100403. doi: 10.1002/cbdv.202100403. Epub 2021 Sep 2.
Three previously undescribed chlorophenyl glycosides, (2,4,6-trichloro-3-hydroxy-5-methoxyphenyl)methyl β-D-glucopyranoside (1), (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (2) and 4-chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (3) were obtained from Lilium regale. The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (2) can inhibit the proliferation of lung carcinoma A549 cells with an IC value of 29 μΜ.
(2,4,6-三氯-3-羟基-5-甲氧基苯基)甲基β-D-吡喃葡萄糖苷（1）、(2,4-二氯-3,5-二甲氧基苯基)甲基 6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖苷（2）和 4-氯-3-甲氧基-5-甲基苯基 6-O-(6-去氧-β-L-甘露吡喃基)-β-D-吡喃葡萄糖苷（3）。通过全面分析光谱数据并结合酸水解衍生化，确定了这些新发现的绝对构型。（2,4-二氯-3,5-二甲氧基苯基）甲基 6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖苷（2）对肺癌 A549 细胞的增殖具有抑制作用，其 IC 值为 29 μM。
