Department of Medicine, Division of Pulmonary, Critical Care and Sleep, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI 48201, USA.
Health Qual Life Outcomes. 2012 Jun 13;10:67. doi: 10.1186/1477-7525-10-67.
Sarcoidosis is a chronic disease with different phenotypic manifestations. Health-related quality of life is an important aspect in sarcoidosis, yet difficult to measure. The objective of this study was to identify clinical markers predictive of poor quality of life in sarcoidosis patients that can be followed over time and targeted for intervention.
We assessed the quality of life of 162 patients with confirmed sarcoidosis in a prospective, cross-sectional study using the Sarcoidosis Health Questionnaire (SHQ) and Short Form-36 Health Survey (SF-36). We evaluated the validity of these questionnaires and sought to identify variables that would best explain the performance scores of the patients.
On multivariate regression analyses, the very best composite model to predict total scores from both surveys was a model containing the distance-saturation product and Borg Dyspnea Scale score at the end of a 6-min walk test. This model could better predict SF-36 scores (R² = 0.33) than SHQ scores (R² = 0.24). Substitution of distanced walked in 6 min for the distance-saturation product in this model resulted in a lesser ability to predict both scores (R² = 0.26 for SF-36; R² = 0.22 for SHQ).
Both the SHQ and SF-36 surveys are valuable tools in the assessment of health-related quality of life in sarcoidosis patients. The best model to predict quality of life among these patients, as determined by regression analyses, included the distance-saturation product and Borg score after the 6-min walk test. Both variables represent easily obtainable clinical parameters that can be followed over time and targeted for intervention.
结节病是一种具有不同表型表现的慢性疾病。健康相关生活质量是结节病的一个重要方面，但难以衡量。本研究的目的是确定可随时间推移进行监测并针对其进行干预的预测结节病患者生活质量较差的临床标志物。
我们使用结节病健康问卷（SHQ）和健康调查简表 36 项（SF-36）在一项前瞻性、横断面研究中评估了 162 例确诊结节病患者的生活质量。我们评估了这些问卷的有效性，并试图确定能够最佳解释患者表现评分的变量。
在多元回归分析中，预测两项调查总评分的最佳综合模型是包含 6 分钟步行试验结束时的距离-饱和度乘积和 Borg 呼吸困难量表评分的模型。该模型能够更好地预测 SF-36 评分（R²=0.33）而非 SHQ 评分（R²=0.24）。在该模型中用 6 分钟步行距离替代距离-饱和度乘积会降低预测两种评分的能力（SF-36 的 R²=0.26；SHQ 的 R²=0.22）。
SHQ 和 SF-36 调查都是评估结节病患者健康相关生活质量的有价值工具。通过回归分析确定的预测这些患者生活质量的最佳模型包括 6 分钟步行试验后的距离-饱和度乘积和 Borg 评分。这两个变量均代表易于获得的临床参数，可随时间推移进行监测并针对其进行干预。
