Sport Doctor, Sportsmed SA, 32 Payneham Road, Stepney, SA, Australia.
Int J Clin Pract. 2012 Jul;66(7):699-704. doi: 10.1111/j.1742-1241.2012.02963.x.
Although some disagreement exists amongst practitioners as to the efficacy of corticosteroid injection into the osteoarthritic knee, this procedure remains the most common reason to perform knee joint injection. There is disagreement too over the most efficacious corticosteroid for the procedure; the dose required at injection; the frequency, and total quantity of corticosteroid that can be injected into the knee. This paper examines the controversies surrounding the efficacy of corticosteroid injection into the osteoarthritic knee, and attempts to provide guidance as to appropriate corticosteroid selection, dose, and treatment interval.
Searches were made of electronic databases, and appropriate papers were identified and hand-searched.
Although numerous investigations have been conducted in an attempt to identify the optimal corticosteroid agent, and its optimal dosing regimen for the intra-articular treatment of osteoarthritis, a consensus has not been established. The current recommendations for dosing interval appear to have arisen as a consequence of a misinterpretation of previously published works. This paper recommends that practitioners refine and individually tailor their selection of agent and dosing regimen to patient needs and clinical response.
尽管从业者对于在骨关节炎膝关节中注射皮质类固醇的疗效存在一些分歧，但该操作仍然是进行膝关节注射的最常见原因。对于该操作最有效的皮质类固醇、注射所需的剂量、皮质类固醇的频率和总量也存在分歧，可以注射到膝关节中。本文探讨了围绕皮质类固醇注射治疗骨关节炎膝关节的疗效的争议，并试图就适当的皮质类固醇选择、剂量和治疗间隔提供指导。
对电子数据库进行了搜索，并确定了合适的论文并进行了手动搜索。
尽管已经进行了许多研究试图确定最佳皮质类固醇药物及其在治疗骨关节炎的关节内的最佳剂量方案，但尚未达成共识。目前关于剂量间隔的建议似乎是由于对先前发表的作品的误解而产生的。本文建议从业者根据患者的需求和临床反应，对药物和剂量方案进行细化和个体化选择。
