Sledziński Tomasz, Proczko-Markuszewska Monika, Kaska Lukasz, Stefaniak Tomasz, Swierczyński Julian
Department of Pharmaceutical Biochemistry, Medical University in Gdańsk.
Pol Przegl Chir. 2012 Apr;84(4):202-7. doi: 10.2478/v10035-012-0033-0.
Serum cystatin C concentration, generally accepted as renal function marker, is associated with cardiovascular risk and metabolic syndrome. Recent studies indicate that cystatin C increases in human obesity and that adipose tissue contributes to enhanced serum cystatin C concentration in obese subjects. The aim of the study was to assess whether a reduction in body and fat mass after bariatric surgery has any impact on serum cystatin C concentrations.
Serum from 27 obese patients were tested before and 6 months after bariatric surgery. Twenty healthy subjects with normal body weight served as controls. Serum cystatin C concentrations were assayed by ELISA.
Serum cystatin C concentrations were significantly higher in obese patients compared with non-obese subjects. Decrease of body and fat mass after bariatric surgery resulted in improvement of several parameters associated with cardiovascular risk and metabolic syndrome, like serum lipids, blood pressure and insulin sensitivity. Surprisingly the mean postoperative serum cystatin C concentration was not significantly different from that before surgery. Serum creatinine and GFR also remained unchanged.
The results presented here suggest that serum cystatin C concentration is not tightly associated with body and fat mass loss in obese patients after bariatric surgery.
血清胱抑素C浓度通常被视为肾功能标志物，与心血管风险和代谢综合征相关。近期研究表明，人类肥胖时胱抑素C升高，且脂肪组织促使肥胖受试者血清胱抑素C浓度升高。本研究旨在评估减肥手术后体重和脂肪量的减少是否对血清胱抑素C浓度有任何影响。
对27例肥胖患者在减肥手术前及术后6个月进行血清检测。20名体重正常的健康受试者作为对照。采用酶联免疫吸附测定法检测血清胱抑素C浓度。
肥胖患者的血清胱抑素C浓度显著高于非肥胖受试者。减肥手术后体重和脂肪量的减少导致与心血管风险和代谢综合征相关的几个参数得到改善，如血脂、血压和胰岛素敏感性。令人惊讶的是，术后血清胱抑素C的平均浓度与手术前相比无显著差异。血清肌酐和肾小球滤过率也保持不变。
此处呈现的结果表明，减肥手术后肥胖患者的血清胱抑素C浓度与体重和脂肪量的减少没有紧密关联。
