干扰素对培养细胞中环核苷酸浓度的影响。
Effect of interferon on concentrations of cyclic nucleotides in cultured cells.
作者信息
Tovey M G, Rochette-Egly C, Castagna M
出版信息
Proc Natl Acad Sci U S A. 1979 Aug;76(8):3890-3. doi: 10.1073/pnas.76.8.3890.
Abstract
Constant intracellular concentrations of both adenosine 3',5'-cyclic-monophosphate (cyclic AMP) and guanosine 3',5'-cyclic-monophosphate (cyclic GMP) were obtained when leukemia L1210 cells were cultivated under steady-state conditions in the chemostat. In this sensitive and controlled system addition of mouse interferon resulted in a rapid (5-10 min) increase in the intracellular concentration of cyclic GMP, which preceded by several hours an increase in the intracellular concentration of cyclic AMP. In contrast to the effect of interferon, addition of prostaglandin E1 induced a rapid increase in the intracellular concentration of cyclic AMP without markedly affecting the intracellular concentration of cyclic GMP. It is suggested that the rapid effect of interferon on cyclic GMP plays a role in mediating some of the effects of interferon on cells.
摘要
当白血病L1210细胞在恒化器中于稳态条件下培养时，可获得细胞内3',5'-环磷酸腺苷（环磷酸腺苷）和3',5'-环磷酸鸟苷（环磷酸鸟苷）的恒定浓度。在这个敏感且可控的系统中，添加小鼠干扰素会导致细胞内环磷酸鸟苷的浓度迅速（5 - 10分钟）升高，这比细胞内环磷酸腺苷浓度的升高提前数小时。与干扰素的作用相反，添加前列腺素E1会导致细胞内环磷酸腺苷的浓度迅速升高，而对细胞内环磷酸鸟苷的浓度没有明显影响。有人认为，干扰素对环磷酸鸟苷的快速作用在介导干扰素对细胞的某些作用中发挥作用。
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本文引用的文献
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