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2
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Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.体内人干扰素刺激后人类单核细胞HLA - DR抗原及Fcγ受体表达增加。
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Cloned human interferon-gamma, but not interferon-beta or -alpha, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines.克隆的人γ干扰素可诱导胎儿单核细胞和髓系白血病细胞系表达HLA - DR决定簇，而β干扰素或α干扰素则无此作用。
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Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells.滋养层细胞中存在人类白细胞抗原（HLA）-DO和HLA-DR的组成型细胞内表达，但不存在HLA-DM的组成型细胞内表达。
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Recombinant interferon-gamma increases HLA-DR synthesis and expression.重组干扰素-γ可增加HLA-DR的合成与表达。
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引用本文的文献

1
Human tumour-induced inhibition of interferon action in vitro: reversal of inhibition by beta-carotene (pro-vitamin A).人肿瘤诱导的体外干扰素作用抑制：β-胡萝卜素（维生素A原）对抑制作用的逆转
Cancer Immunol Immunother. 1984;16(3):189-92. doi: 10.1007/BF00205428.
2
Altered expression of human monocyte Fc receptors in Plasmodium falciparum malaria.恶性疟原虫疟疾中人类单核细胞Fc受体的表达改变
Infect Immun. 1984 Jun;44(3):623-6. doi: 10.1128/iai.44.3.623-626.1984.
3
Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.体内人干扰素刺激后人类单核细胞HLA - DR抗原及Fcγ受体表达增加。
Clin Exp Immunol. 1983 Sep;53(3):739-43.
4
Enhancement of defective monocyte function during immunotherapy with recombinant interferon.重组干扰素免疫治疗期间缺陷单核细胞功能的增强
Cancer Immunol Immunother. 1986;22(2):144-7. doi: 10.1007/BF00199129.
5
Enhancement of monocyte class I and II histocompatibility antigen expression in man by in vivo beta-interferon.体内β-干扰素增强人体单核细胞I类和II类组织相容性抗原表达
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Differential modulating effects of retinoic acid on interferon antiviral activity.维甲酸对干扰素抗病毒活性的差异调节作用。
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7
Human macrophage activation. Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasone.人类巨噬细胞活化。淋巴因子、γ干扰素、α干扰素及地塞米松对体外甘露糖基、岩藻糖基受体活性的调节作用。
J Clin Invest. 1985 Feb;75(2):624-31. doi: 10.1172/JCI111740.
8
Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats.13-顺式维甲酸的免疫抑制活性及对大鼠实验性自身免疫性脑脊髓炎的预防作用
J Clin Invest. 1991 Oct;88(4):1331-7. doi: 10.1172/JCI115438.

本文引用的文献

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Determinant selection is a macrophage dependent immune response gene function.决定簇选择是一种巨噬细胞依赖性免疫反应基因功能。
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2
Augmentation of tumoricidal activity of human monocytes and macrophages by lymphokines.淋巴因子增强人单核细胞和巨噬细胞的杀肿瘤活性。
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Retinoids as regulators of macrophage function.类视黄醇作为巨噬细胞功能的调节剂。
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4
Can dietary beta-carotene materially reduce human cancer rates?膳食中的β-胡萝卜素能显著降低人类患癌率吗？
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Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages.一种可诱导富含Ia阳性巨噬细胞的渗出物的可溶性介质的证明。
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7
A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.一种针对HLA - DR产物的单克隆抗体识别小鼠中的一种多态性Ia决定簇。
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8
Interferon-mediated protection of normal and tumor target cells against lysis by mouse natural killer cells.
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9
Differential effect of interferon expression of IgG- and IgM-Fc receptors on human lymphocytes.IgG和IgM-Fc受体的干扰素表达对人淋巴细胞的差异作用。
J Immunol. 1980 Jun;124(6):2589-95.
10
Interferon enhances the expression of Fc gamma receptors.干扰素可增强Fcγ受体的表达。
J Immunol. 1980 May;124(5):2436-41.

干扰素诱导的单核细胞膜变化：视黄醇和视黄酸的抑制作用。

Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid.

作者信息

Rhodes J, Stokes P

出版信息

Immunology. 1982 Mar;45(3):531-6.

PMID:6174424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555242/
Abstract

The effects of human interferon-beta on human peripheral blood monocyte function were examined in vitro. Interferon-beta was shown to increase substantially the expression of both Fc gamma receptors and HLA-DR antigens defined by monoclonal antibody. Retinol and retinoic acid were found to be antagonistic to these effects of interferon and physiological concentrations were sufficient to inhibit changes in the monocyte membrane induced by relatively high concentrations of interferon.

摘要

在体外研究了人β干扰素对人外周血单核细胞功能的影响。结果显示，β干扰素可显著增加由单克隆抗体所界定的Fcγ受体和HLA - DR抗原的表达。发现视黄醇和视黄酸对干扰素的这些作用具有拮抗作用，生理浓度的视黄醇和视黄酸足以抑制相对高浓度干扰素诱导的单核细胞膜变化。