血浆置换作为系统性红斑狼疮相关弥漫性肺泡出血的挽救治疗方法。
Plasmapheresis as rescue therapy for systemic lupus erthyematosus-associated diffuse alveolar haemorrhage.
作者信息
Claridge Simon, Das Partha, Dorling Anthony, Robson Michael G
机构信息
Department of Renal, Guy's and St Thomas' Hospital Trust, London, UK.
出版信息
BMJ Case Rep. 2011 Mar 15;2011:bcr0220113893. doi: 10.1136/bcr.02.2011.3893.
Abstract
Diffuse alveolar haemorrhage (DAH) is a rare complication of systemic lupus erythematosus (SLE), which can have a potentially lethal outcome. Conventional treatments of the condition include cyclophosphamide and intravenous immunoglobulins. Successful treatment with rituximab and plasmapheresis has also been described. The authors report the case of a woman recently diagnosed with SLE who developed DAH refractory to conventional treatment while on immunosuppressive treatment for class III lupus nephritis whose DAH responded to plasmapheresis.
摘要
弥漫性肺泡出血（DAH）是系统性红斑狼疮（SLE）的一种罕见并发症，可能会导致潜在的致命后果。该病症的传统治疗方法包括环磷酰胺和静脉注射免疫球蛋白。也有使用利妥昔单抗和血浆置换成功治疗的报道。作者报告了一例最近被诊断为SLE的女性病例，该患者在接受III级狼疮性肾炎免疫抑制治疗期间出现了对传统治疗无效的DAH，而其DAH对血浆置换有反应。
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