Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W604-8. doi: 10.1093/nar/gks562. Epub 2012 Jun 14.
Web services application programming interface (API) was developed to provide a programmatic access to the regulatory interactions accumulated in the RegPrecise database (http://regprecise.lbl.gov), a core resource on transcriptional regulation for the microbial domain of the Department of Energy (DOE) Systems Biology Knowledgebase. RegPrecise captures and visualize regulogs, sets of genes controlled by orthologous regulators in several closely related bacterial genomes, that were reconstructed by comparative genomics. The current release of RegPrecise 2.0 includes >1400 regulogs controlled either by protein transcription factors or by conserved ribonucleic acid regulatory motifs in >250 genomes from 24 taxonomic groups of bacteria. The reference regulons accumulated in RegPrecise can serve as a basis for automatic annotation of regulatory interactions in newly sequenced genomes. The developed API provides an efficient access to the RegPrecise data by a comprehensive set of 14 web service resources. The RegPrecise web services API is freely accessible at http://regprecise.lbl.gov/RegPrecise/services.jsp with no login requirements.
Web 服务应用程序编程接口 (API) 是为了提供对在 RegPrecise 数据库（http://regprecise.lbl.gov）中积累的监管交互的编程访问而开发的，RegPrecise 是能源部（DOE）系统生物学知识库中微生物领域转录调控的核心资源。RegPrecise 捕获和可视化 regulogs，这是一组在几个密切相关的细菌基因组中由同源调控因子控制的基因，这些 regulogs 是通过比较基因组学重建的。RegPrecise 2.0 的当前版本包括 >1400 个 regulogs，这些 regulogs 要么由蛋白质转录因子控制，要么由来自 24 个细菌分类群的>250 个基因组中的保守核糖核酸调控基序控制。在 RegPrecise 中积累的参考 regulons 可以作为在新测序的基因组中自动注释调控相互作用的基础。开发的 API 通过一组 14 个 Web 服务资源提供对 RegPrecise 数据的高效访问。RegPrecise Web 服务 API 可在无需登录的情况下免费访问，网址为 http://regprecise.lbl.gov/RegPrecise/services.jsp。
