Vascular Biology Group, Robarts Research Institute, 100 Perth Drive, London, ON, Canada N6A 5K8.
PPAR Res. 2012;2012:857142. doi: 10.1155/2012/857142. Epub 2012 May 30.
Studies in a multitude of models including cell culture, animal and clinical studies demonstrate that citrus-derived flavonoids have therapeutic potential to attenuate dyslipidemia, correct hyperinsulinemia and hyperglycemia, and reduce atherosclerosis. Emerging evidence suggests the metabolic regulators, PPARα and PGC1α, are targets of the citrus flavonoids, and their activation may be at least partially responsible for mediating their metabolic effects. Molecular studies will add significantly to the concept of these flavonoids as viable and promising therapeutic agents to treat the dysregulation of lipid homeostasis, metabolic disease, and its cardiovascular complications.
多项研究表明，包括细胞培养、动物和临床研究在内的研究表明，源自柑橘类的类黄酮具有治疗作用，可以减轻血脂异常、纠正高胰岛素血症和高血糖，并减少动脉粥样硬化。新出现的证据表明，代谢调节剂 PPARα 和 PGC1α 是柑橘类黄酮的作用靶点，它们的激活可能至少部分负责介导其代谢作用。分子研究将极大地丰富这些类黄酮作为治疗脂质稳态失调、代谢疾病及其心血管并发症的可行和有前途的治疗剂的概念。
