中国慢性肝病患者的健康相关生活质量和生存情况。
Health-related quality of life and survival in Chinese patients with chronic liver disease.
出版信息
Health Qual Life Outcomes. 2013 Aug 1;11:131. doi: 10.1186/1477-7525-11-131.
BACKGROUND
To investigate the relationship between health-related quality of life (HRQOL) and survival in Chinese patients with chronic liver disease (CLD).
METHODS
HRQOL was measured with the Chinese version of Short Form 36 (SF-36). SF-36 scores, demographic and clinical data were collected at baseline and after 18 months follow-up. Kaplan-Meier and Cox Proportional Hazard Regression survival analyses were used for interpretation of data. Surviving patients were censored in the analyses.
RESULTS
A total of 415 Chinese patients with CLD and 86 healthy controls were enrolled. During the follow-up period 50 patients died. SF-36 scores in healthy controls and surviving patients were higher compared with those in deceased patients. Scores of physical component summary (PCS) in healthy controls, surviving and deceased patients were 54.1 ± 5.2, 48.9 ± 7.7 and 33.5 ± 8.2 respectively (p < 0.001). Scores of mental component summary (MCS) in healthy controls, surviving and deceased patients were 56.6 ± 8.2, 53.0 ± 5.6 and 37.1 ± 12.1 (p < 0.001) respectively. Survival was significantly associated with PCS and MCS scores, and the presence of ascites.
CONCLUSIONS
HRQOL was associated with survival in patients with CLD. PCS and MCS scores were predictors of survival.
背景
本研究旨在探讨健康相关生活质量（HRQOL）与中国慢性肝病（CLD）患者生存之间的关系。
方法
采用中文版 36 项简短健康调查问卷（SF-36）评估 HRQOL。在基线和 18 个月随访时收集 SF-36 评分、人口统计学和临床数据。Kaplan-Meier 和 Cox 比例风险回归生存分析用于解释数据。分析时对存活患者进行删失。
结果
共纳入 415 例中国 CLD 患者和 86 名健康对照者。随访期间 50 例患者死亡。健康对照组和存活患者的 SF-36 评分均高于死亡患者。健康对照组、存活患者和死亡患者的生理成分综合评分（PCS）分别为 54.1±5.2、48.9±7.7 和 33.5±8.2（p<0.001）。健康对照组、存活患者和死亡患者的心理成分综合评分（MCS）分别为 56.6±8.2、53.0±5.6 和 37.1±12.1（p<0.001）。生存与 PCS 和 MCS 评分以及腹水的存在显著相关。
结论
CLD 患者的 HRQOL 与生存相关。PCS 和 MCS 评分是生存的预测因素。
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