Department of Occupational Diseases and Clinical Toxicology, Beijing Chaoyang Hospital, Beijing, China.
Clin Toxicol (Phila). 2012 Jul;50(6):514-7. doi: 10.3109/15563650.2012.696200. Epub 2012 Jun 18.
Sodium 3,5,6-trichloropyridin-2-ol (STCP) is a widely used intermediate for the production of chlorpyrifos. However, its effect on the health of workers in STCP factories has become increasingly problematic. This article reports four workers who worked in a STCP factory developed peripheral neuropathy in the lower extremities and chloracne-like skin lesions on the whole body. Patches of follicular skin eruptions (mainly blackheads, accompanied by follicular orifice cornification occasionally accompanied by milia-like skin eruptions) were found on the head and face, around the auricle, chest and back, abdomen and scrotum. In one patient, the activity of serum cholinesterase was decreased and recovered slowly, but there were no muscarinic, nicotinic, or central nervous system symptoms. The concentrations of urine STCP detected in four patients were 0.266, 0.066, 0.044, and 0.033 μg/mL.
3,5,6-三氯-2-吡啶醇（STCP）是一种广泛用于生产毒死蜱的中间体。然而，其在 STCP 工厂工人健康方面的影响变得越来越成问题。本文报道了 4 名在 STCP 工厂工作的工人，他们出现了下肢周围神经病和全身类氯痤疮样皮肤损伤。在头部和面部、耳廓周围、胸部和背部、腹部和阴囊发现了片状的毛囊皮肤疹（主要是黑头粉刺，偶尔伴有毛囊口角化和粟粒疹样皮肤疹）。在 1 名患者中，血清胆碱酯酶活性降低，恢复缓慢，但无毒蕈碱、烟碱或中枢神经系统症状。在 4 名患者中检测到的尿 STCP 浓度分别为 0.266、0.066、0.044 和 0.033μg/mL。
