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念珠藻甘油酯，一种从可食用蓝细菌中提取的新型抗菌单酰甘油。

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium .

作者信息

Oku Naoya, Hayashi Saki, Yamaguchi Yuji, Takenaka Hiroyuki, Igarashi Yasuhiro

机构信息

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

MAC Gifu Research Institute, MicroAlgae Corporation, 4-15 Akebono, Gifu 500-8148, Japan.

出版信息

Beilstein J Org Chem. 2023 Feb 9;19:133-138. doi: 10.3762/bjoc.19.13. eCollection 2023.

DOI:10.3762/bjoc.19.13
PMID:36793535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9924362/
Abstract

A new antibacterial 3-monoacyl--glycerol, nostochopcerol (), was isolated from a cultured algal mass of the edible cyanobacterium MAC0804NAN. The structure of compound was established by the analysis of NMR and MS data while its chirality was established by comparison of optical rotation values with synthetically prepared authentics. Compound inhibited the growth of and at MIC of 50 μg/mL and 100 μg/mL, respectively.

摘要

从可食用蓝细菌MAC0804NAN的培养藻体中分离出一种新型抗菌3-单酰基甘油——念珠藻甘油酯（）。通过核磁共振（NMR）和质谱（MS）数据分析确定了化合物的结构，同时通过将旋光值与合成制备的真品进行比较确定了其手性。化合物分别在50μg/mL和100μg/mL的最低抑菌浓度（MIC）下抑制了和的生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0f/9924362/090a2b2a7c10/Beilstein_J_Org_Chem-19-133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0f/9924362/219f67d84b1d/Beilstein_J_Org_Chem-19-133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0f/9924362/090a2b2a7c10/Beilstein_J_Org_Chem-19-133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0f/9924362/219f67d84b1d/Beilstein_J_Org_Chem-19-133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a0f/9924362/090a2b2a7c10/Beilstein_J_Org_Chem-19-133-g003.jpg

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