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重新思考基质:从血液中得到的启示。

Rethinking stroma: lessons from the blood.

机构信息

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, 185 Cambridge Street, Boston, MA 02114, USA.

出版信息

Cell Stem Cell. 2012 Jun 14;10(6):648-649. doi: 10.1016/j.stem.2012.05.011.

DOI:10.1016/j.stem.2012.05.011
PMID:22704500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4020272/
Abstract

Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research.

摘要

基质是所有器官中一个很大程度上未被充分研究的组成部分,它有助于干细胞的生态位。对骨髓中基质成分进行定义的研究已经带来了一些意想不到的发现,这促使进一步的研究。

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本文引用的文献

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Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.内源性骨髓间充质干细胞是维持和再生骨骼过程中具有动态性和命运限定性的参与者。
Cell Stem Cell. 2012 Mar 2;10(3):259-72. doi: 10.1016/j.stem.2012.02.003.
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Endothelial and perivascular cells maintain haematopoietic stem cells.内皮细胞和血管周细胞维持造血干细胞。
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Cell. 2007 Jun 15;129(6):1097-110. doi: 10.1016/j.cell.2007.05.014.
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Tube or not tube: remodeling epithelial tissues by branching morphogenesis.插管与否:通过分支形态发生重塑上皮组织。
Dev Cell. 2003 Jan;4(1):11-8. doi: 10.1016/s1534-5807(02)00410-0.
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The relationship between the spleen colony-forming cell and the haemopoietic stem cell.脾集落形成细胞与造血干细胞之间的关系。
Blood Cells. 1978;4(1-2):7-25.
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Conditions controlling the proliferation of haemopoietic stem cells in vitro.
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