University of California San Francisco, Departments of Laboratory Medicine, San Francisco, CA, 94143, USA.
University of California San Francisco, Departments of Laboratory Medicine, San Francisco, CA, 94143, USA; Diabetes Center, San Francisco, CA, 94143, USA.
Curr Opin Immunol. 2020 Jun;64:34-41. doi: 10.1016/j.coi.2020.03.005. Epub 2020 Apr 24.
Advances in microscopy, genetically modified mice, and single-cell RNA sequencing have begun to deconvolute the composition and function of tissue immune niches. Here we discuss the evidence that the adventitia, the outermost layer of larger blood vessels, is a conserved niche and tissue immune outpost for multiple immune cells, including group 2 innate lymphoid cells (ILC2) and subsets of tissue-resident memory T cells, macrophages, and dendritic cells. We also describe the unique non-immune composition at adventitial regions, including fibroblast-like stromal cell subsets, lymphatic and blood endothelial cells, and neurons, and review how immune-stromal crosstalk impacts regional tissue immunity, organ adaptation, and disease.
显微镜技术、基因修饰小鼠和单细胞 RNA 测序的进展开始解析组织免疫龛的组成和功能。在这里，我们讨论了这样一个证据，即大血管的最外层——外膜是一个保守的龛位和组织免疫前哨，是多种免疫细胞（包括 2 类固有淋巴细胞 (ILC2) 和组织驻留记忆 T 细胞、巨噬细胞和树突状细胞）的栖息地。我们还描述了外膜区域特有的非免疫组成部分，包括成纤维细胞样基质细胞亚群、淋巴管和血管内皮细胞以及神经元，并回顾了免疫-基质细胞相互作用如何影响区域组织免疫、器官适应和疾病。
