生殖细胞干细胞：起源与命运。
Germline stem cells: origin and destiny.
机构信息
Howard Hughes Medical Institute; Skirball Institute, The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
出版信息
Cell Stem Cell. 2012 Jun 14;10(6):729-739. doi: 10.1016/j.stem.2012.05.016.
Abstract
Germline stem cells are key to genome transmission to future generations. Over recent years, there have been numerous insights into the regulatory mechanisms that govern both germ cell specification and the maintenance of the germline in adults. Complex regulatory interactions with both the niche and the environment modulate germline stem cell function. This perspective highlights some examples of this regulation to illustrate the diversity and complexity of the mechanisms involved.
摘要
生殖细胞干细胞是向后代传递基因组的关键。近年来，人们对调控生殖细胞特化和成年个体生殖系维持的机制有了很多了解。与生态位和环境的复杂调控相互作用调节生殖细胞干细胞功能。本观点重点介绍了一些调节的例子，以说明所涉及机制的多样性和复杂性。
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