Kulabukhov V M, Voloshin P V, Kostiukovskaia L S, Bozhko G Kh
Ukr Biokhim Zh (1978). 1987 Mar-Apr;59(2):27-33.
Cholesterol accumulation, quantitative changes and composition of lipoproteins, total proteins of blood serum and protein fractions obtained by acid extraction are studied in hypercholesterinemia dynamics in rabbits. It is found that the initial period of cholesterinosis in blood serum is marked by an increased content of total proteins and proteins extracted by acid followed, however, by substantial lowering of the level of these compounds. The proteins obtained by acid extraction are characterized by more explicit changes. This permits assuming their important role in the pathogenesis of hypercholesterinemia. The obtained results make it possible to state that the investigated proteins possess the alkaline properties. The data available in literature on the ability of alkaline polypeptides to bind cholesterol permit assuming that the investigated proteins have the same properties and, hence, can participate in the molecular mechanisms of cholesterol transport as well as in the processes of synthesis and transformations of separate classes of lipoproteins.
研究了家兔高胆固醇血症动态过程中胆固醇的积累、脂蛋白的定量变化与组成、血清总蛋白以及酸提取获得的蛋白组分。结果发现，血清中胆固醇沉着症的初期表现为总蛋白和酸提取蛋白含量增加，然而随后这些化合物的水平大幅降低。酸提取获得的蛋白表现出更明显的变化。这使得推测它们在高胆固醇血症发病机制中具有重要作用成为可能。所得结果表明所研究的蛋白具有碱性特性。文献中关于碱性多肽结合胆固醇能力的数据使得推测所研究的蛋白具有相同特性成为可能，因此它们可能参与胆固醇转运的分子机制以及不同类脂蛋白的合成和转化过程。
