Kulabukhov V M, Voloshin P V, Bozhko G Kh, Kostiukovskaia L S, Chursina V S
Ukr Biokhim Zh (1978). 1987 Nov-Dec;59(6):19-23.
Guinea pigs after 30, 60 and 90 days of cholesterol, ethanol and cholesterol + ethanol action have been studied for content of cholesterol, lipoproteins of certain classes, quantitative and qualitative composition of blood serum proteins. It has been found that cholesterol does not induce expressed hypercholesterinemia and does not hinder cholesterol accumulation in the blood serum and liver of animals. The specific activity of [3H] cholesterol in the liver under cholesterinosis and its combination with ethanol intoxication for the whole period of experiments is lower than in the control, which testifies to retardation of its renewal. This may stimulate development of pathological hypercholesterinemia-induced states. After 3-month ethanol intoxication the amount of alkaline serum proteins has grown and ethanol retains its action against a background of hypercholesterinemia. The found effect is supposed to reflect one of the compensatory mechanisms for hypercholesterinemia and atherogenesis prevention.
研究了豚鼠在胆固醇、乙醇以及胆固醇 + 乙醇作用30天、60天和90天后，其胆固醇含量、特定类别脂蛋白、血清蛋白的定量和定性组成。结果发现，胆固醇不会引发明显的高胆固醇血症，也不会阻碍动物血清和肝脏中胆固醇的积累。在整个实验期间，胆固醇沉着症及其与乙醇中毒合并情况下肝脏中[3H]胆固醇的比活性低于对照组，这证明其更新受到阻碍。这可能会刺激由病理性高胆固醇血症引发的状态的发展。乙醇中毒3个月后，血清碱性蛋白的量增加，并且乙醇在高胆固醇血症背景下仍保持其作用。所发现的这种效应被认为反映了高胆固醇血症和动脉粥样硬化预防的一种代偿机制。
