3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, 4806-909 Taipas, Guimarães, Portugal.
Macromol Biosci. 2012 Aug;12(8):1106-13. doi: 10.1002/mabi.201200036. Epub 2012 Jun 18.
Membranes of chitosan (CTS) and composite membranes of CTS with bioglass are prepared by solvent casting. The composite membranes are shown to induce the precipitation of apatite upon immersion in SBF. The biomineralization process is followed by measuring the variation of the viscoelastic properties of the membranes immersed in SBF, both online and offline. Non-conventional DMA is used to measure the change in the storage modulus, E', and the loss factor, tan δ, as a function of the immersion in SBF. A simple model is used to estimate the E' of the apatite layer formed in vitro that is about 130 MPa. This work shows that innovate mechanical tests can be useful to characterize the mechanical performance of composites under physiological conditions.
壳聚糖（CTS）膜和 CTS 与生物玻璃的复合膜通过溶剂浇铸法制备。结果表明，复合膜在浸入 SBF 后会诱导磷灰石沉淀。通过测量浸入 SBF 后膜的粘弹性的变化来监测生物矿化过程，包括在线和离线测量。非传统的 DMA 用于测量在 SBF 中的浸泡过程中储能模量 E'和损耗因子 tan δ的变化。使用一个简单的模型来估计体外形成的磷灰石层的 E'约为 130 MPa。这项工作表明，创新的力学测试可用于在生理条件下表征复合材料的力学性能。
