Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, Poland.
Pol J Microbiol. 2012;61(1):3-10.
One third of the earths population is infected with Mycobacterium tuberculosis (Mtb), but only 5-10% of the infected individuals develop active tuberculosis (TB) over their lifetime. The remaining 90-95% stay healthy and are called latently infected individuals. They are the biggest reservoir of the tubercle bacilli and identifying the cases of latent TB is a part of the global plan of TB control. From the clinical point of view detection of latent TB infections (LTBI) in individuals with the highest active TB risk including cases of HIV infection, autoimmune inflammatory diseases or cancer, is a priority. This review summarizes the recent findings in the pathogenesis of latent TB, its diagnosis, treatment and prevention.
地球上有三分之一的人口感染了结核分枝杆菌（Mycobacterium tuberculosis，Mtb），但在他们的一生中，只有 5-10%的感染者会发展为活动性结核病（TB）。其余 90-95%的人保持健康，被称为潜伏性感染者。他们是结核分枝杆菌的最大储存库，确定潜伏性 TB 的病例是全球结核病控制计划的一部分。从临床的角度来看，检测具有最高活动性 TB 风险的个体中的潜伏性 TB 感染（LTBI）是优先事项，这些个体包括 HIV 感染、自身免疫性炎症性疾病或癌症患者。这篇综述总结了潜伏性 TB 的发病机制、诊断、治疗和预防方面的最新发现。
