Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
CNS Neurosci Ther. 2012 Aug;18(8):667-73. doi: 10.1111/j.1755-5949.2012.00354.x. Epub 2012 Jun 19.
We investigated the usefulness of diffusion tensor tractography (DTT) for differentiating between histological pathologies and evaluating white matter (WM) damage resulting from brain tumors. We also sought to categorize the appearance of brain tumor-related WM tract changes.
A total of 18 inpatients with intracranial neoplasms were enrolled. MRI examinations were performed at 3 T using an 8-channel phased array coil. DTT was reconstruction from the raw data of diffusion tensor imaging. WM tract-based analysis of the mean diffusivity (MD), eigenvalues (λ(1) , λ(2) , λ(3) ), and fractional anisotropy (FA) was performed by the manual placement of regions of interest (ROIs) on the color-coded FA maps using DTIStudio software. The axial diffusivity (DA, namely λ(1) ) and the tensor shape (Cl, namely (λ(1) -λ(2) )/3 (λ)) were also compared between groups. P values <0.05 were considered statistically significant.
In cases of low-grade glioma (LGG), the tracts adjacent to the tumors displayed the highest levels of invasion. Tract disruption was mainly observed in cases of high-grade glioma (HGG). We found significant differences regarding the FA, MD, DA, and radial diffusivity between ROIs in patients with LGG or HGG. There were also significant differences in DA and tensor shape (Cl) between patients with LGG and HGG.
Axial diffusivity and Cl may be useful early markers for differentiating between LGG and HGG.
我们旨在探讨弥散张量纤维束成像（DTT）在鉴别组织病理学改变和评估脑肿瘤所致的白质（WM）损伤方面的作用，并对肿瘤相关 WM 纤维束改变的表现进行分类。
共纳入 18 例颅内肿瘤患者。所有患者均在 3.0T 磁共振扫描仪上进行 8 通道相控阵线圈的 MRI 检查。从弥散张量成像的原始数据中重建 DTT。采用 DTIStudio 软件，在彩色编码 FA 图上手动放置感兴趣区（ROI），对 WM 束的平均弥散度（MD）、特征值（λ(1) 、λ(2) 、λ(3) ）和各向异性分数（FA）进行基于纤维束的分析。同时比较各组间的轴向弥散度（DA，即 λ(1) ）和张量形态（Cl，即（λ(1) -λ(2) ）/3 （λ））。P 值＜0.05 被认为具有统计学意义。
低级别胶质瘤（LGG）病例中，肿瘤毗邻的纤维束受侵程度最高。高级别胶质瘤（HGG）病例中主要表现为纤维束中断。LGG 和 HGG 患者的 ROI 间 FA、MD、DA 和径向弥散度存在显著差异。LGG 和 HGG 患者的 DA 和张量形态（Cl）也存在显著差异。
轴向弥散度和 Cl 可能是鉴别 LGG 和 HGG 的早期有用标志物。
