Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.
Behav Neurol. 2013;26(1-2):55-66. doi: 10.3233/BEN-2012-110240.
Spelling - a core language skill - is commonly affected in neurological diseases such as stroke and Primary Progressive Aphasia (PPA). We present two case studies of the same spelling therapy (learning of phoneme-to-grapheme correspondences with help from key words) in two participants: one who had a stroke and one with PPA (logopenic variant). Our study highlights similarities and differences in the time course of each indivdual's therapy. The study evaluates the effectiveness and generalization of treatment in each case, i.e. whether the treatment affected the trained items and/or untrained items, and whether or not the treatment gains were maintained after the end of therapy. Both participants were able to learn associations between phonemes and graphemes as well as between phonemes and words. Reliable generalization to untrained words was shown only for the participant with post-stroke aphasia, but we were not able to test generalization to untrained words in the individual with PPA. The same spelling therapy followed a different time course in each case. The participant with post-stroke aphasia showed a lasting effect of improved spelling, but we were unable to assess maintenance of improvement in the participant with PPA. We discuss these differences in light of the underlying nature of each disease.
拼写——一项核心语言技能——在中风和原发性进行性失语症（PPA）等神经疾病中通常会受到影响。我们介绍了两名参与者接受相同拼写治疗（通过关键词学习音素到字形对应关系）的两个案例研究：一名患有中风，一名患有 PPA（失语法变体）。我们的研究强调了每个个体治疗过程中的相似点和不同点。该研究评估了每种情况下治疗的有效性和泛化，即治疗是否影响了训练项目和/或未训练项目，以及治疗结束后治疗效果是否得以维持。两名参与者都能够学习音素与字形以及音素与单词之间的关联。只有患有中风后失语症的参与者能够可靠地将治疗效果泛化到未训练的单词上，但我们无法测试患有 PPA 的个体的未训练单词的泛化能力。相同的拼写治疗在每种情况下遵循不同的时间过程。患有中风后失语症的参与者的拼写得到了持久的改善，但我们无法评估患有 PPA 的参与者的改善是否得以维持。我们根据每种疾病的潜在性质讨论了这些差异。
