Wojciechowska Wiktoria, Li Yan, Stolarz-Skrzypek Katarzyna, Kawecka-Jaszcz Kalina, Staessen Jan A, Wang Ji-Guang
The First Department of Cardiology and Hypertension, Jagiellonian University Medical College Kraków, Poland.
Front Physiol. 2012 Jun 15;3:209. doi: 10.3389/fphys.2012.00209. eCollection 2012.
As arteries become stiffer with aging, reflected waves move faster and augment late systolic pressure. Few studies have described the age-related changes in both peripheral and central systolic blood pressures in populations. We investigated the age dependency of peripheral (pSBP) and central (cSBP) systolic pressure and pressure amplification (i.e., difference between peripheral and central SBP) in randomly selected participants from European and Chinese populations. Data were collected in 1420 Europeans (mean age, 41.7 years) and 2044 (mean age, 45.1 years) Chinese. In cross-sectional analyses of the population samples cSBP consistently increased more with age than pSBP with the age-related increases being greater in women than men. Repeat assessment of pSBP and cSBP in 398 Europeans and 699 Chinese at a median interval approximately 4 years of follow-up confirmed that also within subjects cSBP rose steeper with aging than pSBP. In conclusion, with aging, pSBP approximates to cSBP. This might explain why in older subjects pSBP becomes the main predictor of cardiovascular complications.
随着动脉随着年龄增长而变得更僵硬，反射波传播得更快并增大收缩末期压力。很少有研究描述人群中外周和中心收缩压的年龄相关变化。我们在来自欧洲和中国人群的随机选择参与者中，研究了外周收缩压（pSBP）和中心收缩压（cSBP）以及压力放大（即外周和中心收缩压之间的差值）的年龄依赖性。在1420名欧洲人（平均年龄41.7岁）和2044名中国人（平均年龄45.1岁）中收集了数据。在对人群样本的横断面分析中，cSBP随年龄增长始终比pSBP增加得更多，且与年龄相关的增加在女性中比男性更大。在398名欧洲人和699名中国人中，在中位随访间隔约4年时对pSBP和cSBP进行重复评估，证实了在个体内部cSBP随年龄增长也比pSBP上升得更陡。总之，随着年龄增长，pSBP接近cSBP。这可能解释了为什么在老年受试者中pSBP成为心血管并发症的主要预测因素。
