Juch Herbert, Blaschitz Astrid, Dohr Gottfried, Hutter Heinz
Institute of Cell Biology, Histology and Embryology, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
Wien Med Wochenschr. 2012 May;162(9-10):196-200. doi: 10.1007/s10354-012-0070-7.
Placental trophoblast cells of the semi-allogenic human conceptus invade deeply into maternal uterine tissue. From a classical immunoiogic point of view this invasion and the following growth and development of the fetus in the uterus have to be tolerated by a pregnant woman's immune system. Among the various possible protective mechanisms that may be involved, the unique expression pattern of HLA class I molecules seems to be relevant. Besides many other differences between placentation and organ transplantation, this extraordinary HLA class I expression on trophoblast explains why pregnancy should not be considered an immunologic paradox but rather a fascinating example of a very special challenge for the female immune system.
半同种异体人类胚胎的胎盘滋养层细胞会深深侵入母体子宫组织。从经典免疫学角度来看，这种侵入以及随后胎儿在子宫内的生长发育必须被孕妇的免疫系统所耐受。在可能涉及的各种潜在保护机制中，HLA I类分子独特的表达模式似乎与之相关。除了胎盘形成与器官移植之间的许多其他差异外，滋养层细胞上这种特殊的HLA I类分子表达解释了为什么怀孕不应被视为免疫悖论，而应被看作是女性免疫系统面临的一个非常特殊挑战的有趣例子。
