Health Management Research Centre, Baqiyatallah University of Medical Sciences, 1435814717 Tahran, Iran.
Cardiol Res Pract. 2012;2012:973974. doi: 10.1155/2012/973974. Epub 2012 Jun 10.
Objective. To examine the changes in health-related quality of life (HRQoL) in patients with coronary artery disease (CAD) in terms of age, gender, and treatment strategy in Iran. Methods and Materials. Forty-nine patients responded to the Iranian version of the 36-item short form (SF-36) questionnaire to evaluate the HRQoL at first and third year after treatment. The paired and independent Wilcoxon rank-sum tests were used for within and between comparisons, respectively. Multivariate regression analysis was used to analyze the predictors of changes at HRQoL. Results. In general, during followup, the mental component summary scale improved, and the physical component summary scale declined. The results of multiple regression showed that the score at the first year post-treatment was the main predictor of HRQoL at follow up. Moreover, after adjusting for other covariates, receiving PTCA and being at older age were related to lower scores at followup, but these were not statistically significant in most cases. Conclusion. The HRQoL significantly changed from one to three years after treatment in patients with CAD. While, the physical health deteriorated during two-year follow up, mental health improved at the same time period. Generally, there were no significant differences at changes of HRQoL in terms of treatment, age, and gender.
在伊朗，研究年龄、性别和治疗策略对冠心病（CAD）患者健康相关生活质量（HRQoL）变化的影响。
49 名患者在治疗后第 1 年和第 3 年时用伊朗版的 36 项简短健康调查问卷（SF-36）来评估 HRQoL。采用配对和独立 Wilcoxon 秩和检验进行组内和组间比较。采用多元回归分析来分析 HRQoL 变化的预测因素。
一般来说，在随访期间，心理成分综合量表得分增加，而生理成分综合量表得分下降。多因素回归分析结果表明，治疗后第 1 年的评分是随访时 HRQoL 的主要预测因素。此外，在调整其他协变量后，接受经皮冠状动脉介入治疗（PTCA）和年龄较大与随访时的低评分有关，但在大多数情况下没有统计学意义。
CAD 患者在治疗后 1 年到 3 年内的 HRQoL 显著变化。虽然在两年的随访期间，生理健康状况恶化，但心理健康状况同时有所改善。一般来说，在治疗、年龄和性别方面，HRQoL 的变化没有显著差异。
