工程化 H5N1 禽流感病毒以研究人类适应性。
Engineering H5N1 avian influenza viruses to study human adaptation.
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nature. 2012 Jun 20;486(7403):335-40. doi: 10.1038/nature11170.
Abstract
Two studies of H5N1 avian influenza viruses that had been genetically engineered to render them transmissible between ferrets have proved highly controversial. Divergent opinions exist about the importance of these studies of influenza transmission and about potential 'dual use' research implications. No consensus has developed yet about how to balance these concerns. After not recommending immediate full publication of earlier, less complete versions of the studies, the United States National Science Advisory Board for Biosecurity subsequently recommended full publication of more complete manuscripts; however, controversy about this and similar research remains.
摘要
两项关于 H5N1 禽流感病毒的研究已经被证明极具争议性，这些研究通过基因工程使病毒能够在雪貂之间传播。人们对这些流感传播研究的重要性以及潜在的“双重用途”研究意义存在不同看法。对于如何平衡这些关注点，目前尚未达成共识。在没有建议立即全面公布之前那些不完整的、较早期版本的研究之后，美国生物安保国家科学咨询委员会随后建议全面公布更完整的手稿；然而，对于这一研究和类似研究的争议仍然存在。
相似文献
1
Engineering H5N1 avian influenza viruses to study human adaptation.工程化 H5N1 禽流感病毒以研究人类适应性。
Nature. 2012 Jun 20;486(7403):335-40. doi: 10.1038/nature11170.
2
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets.实验性改造的流感 H5 HA 可使重组 H5 HA/H1N1 病毒在雪貂中通过呼吸道飞沫传播。
Nature. 2012 May 2;486(7403):420-8. doi: 10.1038/nature10831.
3
Mutant-flu paper published.突变流感论文发表。
Nature. 2012 May 2;485(7396):13-4. doi: 10.1038/485013a.
4
Publishing risky research.发表有风险的研究。
Nature. 2012 May 2;485(7396):5. doi: 10.1038/485005a.
5
Pause on avian flu transmission studies.暂停禽流感传播研究。
Nature. 2012 Jan 20;481(7382):443. doi: 10.1038/481443a.
6
Public health and biosecurity. Restricted data on influenza H5N1 virus transmission.公共卫生与生物安全。关于H5N1型流感病毒传播的受限数据。
Science. 2012 Feb 10;335(6069):662-3. doi: 10.1126/science.1218376. Epub 2012 Jan 19.
7
Freeze on mutant-flu research set to thaw.针对变异流感研究的冻结措施即将解冻。
Nature. 2012 Jun 26;486(7404):449-50. doi: 10.1038/486449a.
8
Post-mortem on mutant flu.变异流感尸检报告。
Nature. 2012 Apr 10;484(7393):150-1. doi: 10.1038/484150a.
9
Dual-use research: Self-censorship is not enough.两用研究：自我审查是不够的。
Nature. 2012 Dec 20;492(7429):345-7. doi: 10.1038/492345a.
10
Great expectations--ethics, avian flu and the value of progress.厚望——伦理、禽流感和进步的价值。
J Med Ethics. 2013 Apr;39(4):209-13. doi: 10.1136/medethics-2012-100712. Epub 2012 Oct 30.
引用本文的文献
1
Emerging Bioanalytical Devices and Platforms for Rapid Detection of Pathogens in Environmental Samples.用于快速检测环境样本中病原体的新兴生物分析设备和平台
Micromachines (Basel). 2022 Jul 8;13(7):1083. doi: 10.3390/mi13071083.
2
Characterizing Receptor Flexibility to Predict Mutations That Lead to Human Adaptation of Influenza Hemagglutinin.鉴定受体灵活性以预测导致流感血凝素发生人类适应性突变的方法。
J Chem Theory Comput. 2022 Aug 9;18(8):4995-5005. doi: 10.1021/acs.jctc.1c01044. Epub 2022 Jul 11.
3
Review-Chemical and Biological Sensors for Viral Detection.用于病毒检测的化学和生物传感器综述。
J Electrochem Soc. 2020 Jan;167(3):037523. doi: 10.1149/2.0232003JES. Epub 2019 Dec 19.
4
The 1918 Influenza Pandemic and Its Legacy.1918 年流感大流行及其影响
Cold Spring Harb Perspect Med. 2020 Oct 1;10(10):a038695. doi: 10.1101/cshperspect.a038695.
5
The 1918 influenza pandemic: 100 years of questions answered and unanswered.1918 年流感大流行：百年未解之谜。
Sci Transl Med. 2019 Jul 24;11(502). doi: 10.1126/scitranslmed.aau5485.
6
Making Universal Influenza Vaccines: Lessons From the 1918 Pandemic.研发通用流感疫苗：从 1918 年大流感中汲取的教训。
J Infect Dis. 2019 Apr 8;219(Suppl_1):S5-S13. doi: 10.1093/infdis/jiy728.
7
Establishment and evaluation of a theater influenza monitoring platform.建立和评估一个剧场流感监测平台。
Mil Med Res. 2017 Nov 20;4(1):35. doi: 10.1186/s40779-017-0144-3.
8
A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?H10流感病毒血凝素的唾液酸聚糖受体特异性图谱——一种濒临大流行的禽流感病毒的写照？
Vaccines (Basel). 2017 Dec 13;5(4):51. doi: 10.3390/vaccines5040051.
9
MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction.微小 RNA-302a 抑制甲型流感病毒刺激的干扰素调节因子-5 表达和细胞因子风暴诱导。
J Biol Chem. 2017 Dec 29;292(52):21291-21303. doi: 10.1074/jbc.M117.805937. Epub 2017 Oct 18.
10
Mapping influenza transmission in the ferret model to transmission in humans.将雪貂模型中的流感传播情况映射到人类的传播情况。
Elife. 2015 Sep 2;4:e07969. doi: 10.7554/eLife.07969.
本文引用的文献
1
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets.实验性改造的流感 H5 HA 可使重组 H5 HA/H1N1 病毒在雪貂中通过呼吸道飞沫传播。
Nature. 2012 May 2;486(7403):420-8. doi: 10.1038/nature10831.
2
Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells.适应性突变可补偿 H5N1 病毒 RNA 在培养的人细胞中的复制缺陷。
Nat Commun. 2012 May 1;3:802. doi: 10.1038/ncomms1804.
3
Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret.甲型 H1N1 流感病毒在雪貂中经呼出气溶胶传播的研究
PLoS One. 2012;7(4):e33118. doi: 10.1371/journal.pone.0033118. Epub 2012 Apr 3.
4
No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8).没有证据表明与感染了犬流感 A 病毒（H3N8）的犬密切接触的马会发生水平感染。
Acta Vet Scand. 2012 Apr 16;54(1):25. doi: 10.1186/1751-0147-54-25.
5
IFITM3 restricts the morbidity and mortality associated with influenza.IFITM3 限制了流感相关的发病率和死亡率。
Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921.
6
Mammalian-transmissible H5N1 influenza: facts and perspective.哺乳动物传播的 H5N1 流感：事实与展望。
mBio. 2012 Feb 24;3(2):e00045-12. doi: 10.1128/mBio.00045-12. Print 2012.
7
Seroevidence for H5N1 influenza infections in humans: meta-analysis.人类感染 H5N1 流感的血清学证据：荟萃分析。
Science. 2012 Mar 23;335(6075):1463. doi: 10.1126/science.1218888. Epub 2012 Feb 23.
8
Dangerous for ferrets: lethal for humans?对雪貂危险：对人类致命？
BMC Biol. 2012 Feb 20;10:10. doi: 10.1186/1741-7007-10-10.
9
H5N1 influenza viruses: facts, not fear.H5N1 流感病毒：事实，而非恐惧。
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2211-3. doi: 10.1073/pnas.1121297109. Epub 2012 Jan 25.
10
Mammalian-transmissible H5N1 influenza: the dilemma of dual-use research.哺乳动物传播的 H5N1 流感：两用研究的困境。
mBio. 2012 Jan 31;3(1). doi: 10.1128/mBio.00005-12. Print 2012.
Zotero 插件