Ozer Tugba, Geiss Brian J, Henry Charles S
Department of Chemistry, Colorado State University, USA.
Yildiz Technical University, Faculty of Chemistry-Metallurgy, Department of Bioengineering, Istanbul, Turkey.
J Electrochem Soc. 2020 Jan;167(3):037523. doi: 10.1149/2.0232003JES. Epub 2019 Dec 19.
Infectious diseases commonly occur in contaminated water, food, and bodily fluids and spread rapidly, resulting in death of humans and animals worldwide. Among infectious agents, viruses pose a serious threat to public health and global economy because they are often difficult to detect and their infections are hard to treat. Since it is crucial to develop rapid, accurate, cost-effective, and in-situ methods for early detection viruses, a variety of sensors have been reported so far. This review provides an overview of the recent developments in electrochemical sensors and biosensors for detecting viruses and use of these sensors on environmental, clinical and food monitoring. Electrochemical biosensors for determining viruses are divided into four main groups including nucleic acid-based, antibody-based, aptamer-based and antigen-based electrochemical biosensors. Finally, the drawbacks and advantages of each type of sensors are identified and discussed.
传染病通常发生在受污染的水、食物和体液中，并迅速传播，导致全球范围内的人类和动物死亡。在传染病原体中，病毒对公众健康和全球经济构成严重威胁，因为它们往往难以检测，且其感染难以治疗。由于开发快速、准确、经济高效的原位病毒早期检测方法至关重要，到目前为止已报道了多种传感器。本文综述了用于检测病毒的电化学传感器和生物传感器的最新进展，以及这些传感器在环境、临床和食品监测中的应用。用于检测病毒的电化学生物传感器主要分为四类，包括基于核酸的、基于抗体的、基于适体的和基于抗原的电化学生物传感器。最后，对每种类型传感器的缺点和优点进行了识别和讨论。
