Department of Anesthesiology Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Microbiol Immunol. 2012 Oct;56(10):708-18. doi: 10.1111/j.1348-0421.2012.00488.x.
The aim of the present study was to determine the correlations between leukocyte cell-derived chemotaxin 2 (LECT2) and inflammation-related variables in human inflammatory disease. Plasma samples from 23 septic patients who had been admitted to the intensive care unit (ICU) of our institution and 31 volunteers were used. Plasma LECT2 concentrations were examined retrospectively and compared with those of various inflammatory cytokines and routine laboratory data. The LECT2 concentrations of the septic patients at the time of ICU entry (5.3 ± 4.1 ng/mL) were significantly lower than those of the volunteers (19.7 ± 3.4 ng/mL) and these concentrations had significantly increased by the time of ICU discharge. Individual analyses showed that the LECT2 concentrations of all 19 patients had increased by the time of ICU discharge. A combination of LECT2 and C-reactive protein (CRP) concentrations was capable of discriminating the acute and recovery phases of sepsis to a degree similar to those of the combinations of CRP concentration and percentage of neutrophils, CRP concentration and percentage of immature white blood cells, or CRP and interleukin-6 concentrations. Thus, the LECT2 concentration correlates with the severity of systemic inflammation in patients with sepsis. LECT2 may be a reliable diagnostic indicator of human inflammatory diseases.
本研究旨在探讨白细胞细胞来源趋化因子 2（LECT2）与人类炎症性疾病中炎症相关变量之间的相关性。使用了我院重症监护病房（ICU）收治的 23 例脓毒症患者和 31 名志愿者的血浆样本。回顾性检测了血浆 LECT2 浓度，并与各种炎症细胞因子和常规实验室数据进行了比较。脓毒症患者 ICU 入院时（5.3±4.1ng/ml）的 LECT2 浓度明显低于志愿者（19.7±3.4ng/ml），且在 ICU 出院时明显升高。个体分析显示，19 名患者的 LECT2 浓度在 ICU 出院时均有所升高。LECT2 浓度与 C 反应蛋白（CRP）浓度的组合能够在一定程度上区分脓毒症的急性期和恢复期，与 CRP 浓度与中性粒细胞百分比、CRP 浓度与不成熟白细胞百分比或 CRP 与白细胞介素-6 浓度的组合具有相似的区分能力。因此，LECT2 浓度与脓毒症患者全身炎症的严重程度相关。LECT2 可能是人类炎症性疾病的可靠诊断指标。
