School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Arch Pharm Res. 2013 Dec;36(12):1516-24. doi: 10.1007/s12272-013-0143-1. Epub 2013 May 24.
Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), one new flavonolignan 23-o-acetylsilychristin A (3), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds, including ten flavonolignans (5-14) and three thymol derivatives (15-17) were isolated from the aerial part of Inula wissmanniana. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.
从旋覆花的地上部分分离得到了两个新的肌醇衍生物，4-乙酸-1,2,3,5-四（2-甲基-2-丁烯酸）肌醇（1）和 3-乙酸-1,2,4,5-四（2-甲基-2-丁烯酸）肌醇（2），一个新的类黄酮木脂素 23-O-乙酰基硅基基督醇 A（3）和一个新的麝香草酚衍生物 3-羟基-4-（2-羟基-1-甲基乙基）苯甲酸（4），以及 13 个已知化合物，包括 10 个类黄酮木脂素（5-14）和 3 个麝香草酚衍生物（15-17）。新化合物的结构通过详细的光谱分析，包括 HRESIMS 和 2D-NMR 光谱数据来阐明。所有化合物均首次从该植物中分离得到。测试了这些化合物对 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 产生的抗炎活性。
