Laboratory of Cellular and Molecular Immunology, GIGA-Research and Faculty of Veterinary Medicine, B34, University of Liege, 1 Avenue de l'Hopital, B-4000 Liège, Belgium.
Nat Rev Immunol. 2012 Jun 22;12(7):479-91. doi: 10.1038/nri3247.
The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines.
目前，人们对新型疫苗接种策略的需求很高，特别是需要帮助对抗一些有问题的细胞内病原体，如 HIV 和疟原虫寄生虫。在过去的十年中，识别宿主受体以识别病原体衍生的核酸的方法揭示了核酸感应在触发对细胞内病原体的免疫中的重要作用。本综述首先介绍了我们对核酸感应免疫机制的当前理解。然后，我们解释了核酸感应机制的研究不仅揭示了它们在驱动许多现有疫苗介导的反应中的核心作用，还揭示了如何利用它们来设计新疫苗。
