细菌与基质表面的黏附力和生物膜对抗生素的敏感性。
Bacterial adhesion forces with substratum surfaces and the susceptibility of biofilms to antibiotics.
机构信息
Department of Biomedical Engineering, W. J. Kolff Institute, University Medical Center Groningen, and University of Groningen, Groningen, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2012 Sep;56(9):4961-4. doi: 10.1128/AAC.00431-12. Epub 2012 Jun 25.
Abstract
Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 ± 0.03 to -0.51 ± 0.62 nN) than to uncoated silicone rubber (-1.05 ± 0.46 to -5.1 ± 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.
摘要
生物膜引起的生物材料相关性感染对抗生素治疗有抗性，通常需要更换感染的植入物。在这里，我们研究了未涂层和聚合物刷涂层硅橡胶上生物膜的细菌粘附力和抗生素敏感性。9 株金黄色葡萄球菌、表皮葡萄球菌和铜绿假单胞菌在刷涂层硅橡胶上的粘附力比未涂层硅橡胶上的弱（-0.05 ± 0.03 至-0.51 ± 0.62 nN）。与未涂层硅橡胶相比，弱粘附力的生物膜在聚合物刷涂层上仍处于浮游状态，对庆大霉素敏感。
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