[基于总量子统计矩的半夏厚朴汤水煎液提取物HPLC指纹图谱定性定量评价]
[Qualitative and quantitative assessment on the HPLC fingerprint of BYHW decoction extract by total quantum statistical moment].
作者信息
Zhou Jin, Deng Kai-Wen, He Fu-Yuan, Liu Wen-Long
机构信息
College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China.
出版信息
Zhong Yao Cai. 2012 Jan;35(1):133-7.
OBJECTIVE
To analyse the HPLC fingerprint of BYHW decoction extract.
METHODS
HPLC fingerprint of ten BYHW decoction extracts were established to calculate correlation parameter by total quantum statistcol moment (TQSM).
RESULTS
The TQSM's parameters of ten BYHW decoction extract, such as AUC(T) was 1.976 x 10(7) microV x s, AUCPW(T) was 3.807 x 10(4) microV x s/mg, MCRT(T) was 13.72 min, VCRT(T) was 15.74 min2, and total quantum concentration was 519.0 mg/mL.
CONCLUSION
The total quantum statistic moment can be used to characterize the curve of chromatographic fingerprints with expressive parameters above, also to quantitative analyses by AUC(T) and qualitative analyses by AUCPW(T), MCRT(T) and VCRT(T).
目的
分析半夏厚朴汤水煎液提取物的高效液相色谱指纹图谱。
方法
建立10批半夏厚朴汤水煎液提取物的高效液相色谱指纹图谱，采用总量统计矩法计算相关参数。
结果
10批半夏厚朴汤水煎液提取物的总量统计矩参数，如AUC(T)为1.976×10(7)微伏·秒，AUCPW(T)为3.807×10(4)微伏·秒/毫克，MCRT(T)为13.72分钟，VCRT(T)为15.74分钟²，总量浓度为519.0毫克/毫升。
结论
总量统计矩可用于表征具有上述特征参数的色谱指纹图谱曲线，也可通过AUC(T)进行定量分析，通过AUCPW(T)、MCRT(T)和VCRT(T)进行定性分析。
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