诺如病毒 P 粒子：一种亚病毒纳米颗粒，可用于开发针对诺如病毒、轮状病毒和流感病毒的疫苗。
Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus.
机构信息
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.
出版信息
Nanomedicine (Lond). 2012 Jun;7(6):889-97. doi: 10.2217/nnm.12.62.
Abstract
Noroviruses (NoVs) are important pathogens causing epidemic acute gastroenteritis that affects millions of people worldwide. The protruding (P) domain of the NoV capsid protein, the surface antigen of NoV, forms a 24-mer subviral particle called the P particle that is an excellent candidate vaccine against NoVs. The P particles are easily produced in Escherichia coli, highly stable and highly immunogenic. Each P domain has three surface loops that can be used for foreign antigen presentation, making the P particles a useful platform for vaccine development against other infectious diseases. This article summarizes the discovery, structure, development and applications of the P particles as a vaccine against NoVs, as well as a vaccine platform against rotavirus, influenza virus and possibly other pathogens in the future.
摘要
诺如病毒（NoV）是导致全球数百万人感染的重要病原体，引发流行性急性肠胃炎。NoV 衣壳蛋白的突出（P）结构域是 NoV 的表面抗原，可形成一种 24 个亚单位的亚病毒颗粒，称为 P 颗粒，是 NoV 的理想候选疫苗。P 颗粒在大肠杆菌中很容易产生，高度稳定且具有高度免疫原性。每个 P 结构域有三个表面环，可用于展示外源抗原，使 P 颗粒成为针对其他传染病的疫苗开发的有用平台。本文总结了 P 颗粒作为 NoV 疫苗的发现、结构、开发和应用，以及作为轮状病毒、流感病毒疫苗平台，未来可能还有其他病原体。
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