Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan.
Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata City, Japan.
Cancer Sci. 2018 Dec;109(12):3671-3678. doi: 10.1111/cas.13802. Epub 2018 Oct 15.
Many inflammatory mediators are involved in the process of carcinogenesis and cancer progression. In addition to cytokines and chemokines, lipid mediators have recently attracted attention as signaling molecules associated with inflammatory diseases. Sphingosine-1-phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival and migration, immune cell recruitment, angiogenesis and lymphangiogenesis. S1P also plays a significant role in inflammation and cancer. The gradation of S1P concentration in the blood, lymph and tissue regulates lymphocyte trafficking, an important component of inflammation. Furthermore, cancer cells produce elevated levels of S1P, contributing to the tumor microenvironment and linking cancer and inflammation. Future technological advances may reveal greater detail about the mechanisms of S1P regulation in the tumor microenvironment and the contribution of S1P to cancer progression. Considering the critical role of S1P in linking inflammation and cancer, it is possible that the S1P signaling pathway could be a novel therapeutic target for cancers with chronic inflammation.
许多炎症介质参与了致癌和癌症进展的过程。除了细胞因子和趋化因子外，脂质介质最近作为与炎症性疾病相关的信号分子引起了关注。鞘氨醇-1-磷酸（S1P）是一种具有多种功能的脂质介质，可调节细胞存活和迁移、免疫细胞募集、血管生成和淋巴管生成。S1P 在炎症和癌症中也起着重要作用。血液、淋巴和组织中 S1P 浓度的梯度调节淋巴细胞的迁移，这是炎症的一个重要组成部分。此外，癌细胞产生高水平的 S1P，有助于肿瘤微环境的形成，并将癌症和炎症联系起来。未来的技术进步可能会更详细地揭示 S1P 在肿瘤微环境中的调节机制以及 S1P 对癌症进展的贡献。考虑到 S1P 在连接炎症和癌症方面的关键作用，S1P 信号通路可能成为具有慢性炎症的癌症的一种新的治疗靶点。
