Valet V, Lohmann C P, Maier M
Klinik und Poliklinik für Augenheilkunde, Klinikum rechts der Isar der Technischen Universität München, München, Deutschland.
Ophthalmologe. 2012 Sep;109(9):879-87. doi: 10.1007/s00347-012-2588-x.
The aim was to describe the morphological alterations of the retina seen in spectral domain optical coherence tomography (SD-OCT) of eyes with central serous chorioretinopathy (CSC).
Data of patients in the database with CSC examined with SD-OCT scans (n = 50) and fluorescein angiography (FA) were analyzed for representative cases exhibiting significant changes of the retinal structure allowing a direct comparison of SD-OCT with FA images and a description of the findings.
Apart from the 3 well-known CCS types [type I shows only subretinal fluid (SRF), type II only serous pigment epithelial detachment (PED) and the intermediate type showing both SRF and PED] hybrid forms were also observed in multifocal CSC, for example type I and type II next to each other. Of the patients 1 showed transformation from type II to type I over a period of 3 months. Small bulges of the retinal pigment epithelium (RPE) seen in OCT images could be angiographically related to leakage spots. Degenerative changes with subretinal granular sediments, patchy defects in the photoreceptor layer, granular alterations of the RPE and atrophy of the RPE and neuroretina were particularly observed in chronic CSC.
Spectral domain OCT is a valuable imaging technology enabling detailed visualization of retinal changes in patients with CSC. It gives access to a better understanding of the disease mechanisms and may provide a new approach to the classification and understanding of CSC.
目的是描述中心性浆液性脉络膜视网膜病变（CSC）患者的光谱域光学相干断层扫描（SD-OCT）中所见视网膜的形态学改变。
分析数据库中接受SD-OCT扫描（n = 50）和荧光素血管造影（FA）检查的CSC患者的数据，以获取显示视网膜结构有显著变化的代表性病例，从而能够直接比较SD-OCT与FA图像并描述研究结果。
除了3种众所周知的CSC类型[I型仅显示视网膜下液（SRF），II型仅显示浆液性色素上皮脱离（PED），中间型同时显示SRF和PED]外，在多灶性CSC中还观察到混合形式，例如相邻的I型和II型。1例患者在3个月内从II型转变为I型。OCT图像中所见视网膜色素上皮（RPE）的小隆起在血管造影上可能与渗漏点相关。在慢性CSC中特别观察到伴有视网膜下颗粒状沉积物的退行性改变、光感受器层的斑片状缺损、RPE的颗粒状改变以及RPE和神经视网膜的萎缩。
光谱域OCT是一种有价值的成像技术，能够详细显示CSC患者的视网膜变化。它有助于更好地理解疾病机制，并可能为CSC的分类和理解提供新方法。
