Mediterranean Ophthalmology Center, Rome, Italy.
Retina. 2011 Mar;31(3):553-8. doi: 10.1097/IAE.0b013e3181eef3eb.
To assess morphologic differences in pigment epithelial detachment (PED) with en face optical coherence tomography in central serous chorioretinopathy (CSC) and age-related macular degeneration (AMD).
We recruited 30 eyes of 22 patients with PED. Nine eyes had a clinical diagnosis of CSC and 21 had AMD. All patients were assessed with en face optical coherence tomography. Morphologic PED aspects were estimated on C-scans and classified according to shape, inner silhouette, content, wall aspects, wall thickness, and size.
Pigment epithelial detachment shape was predominantly circular (88.8%) in CSC and irregular or with multilobular features in AMD (76.2%). The PED inner silhouette had a smooth aspect (88.9%) in CSC and a slightly granular aspect or granular profile in AMD (100%). Clear PED content was the most characteristic feature of CSC (88.9%) but not of AMD. In CSC, PED morphologic wall aspect was uniform or slightly irregular (100%), while in AMD, it was slightly irregular (52.4%) or irregular (47.6%). Pigment epithelial detachment wall thickness and dimensions were larger in AMD than in CSC. Statistically significant differences were observed between CSC and AMD concerning PED inner silhouette, contents, wall aspects, and wall thickness measurements.
En face optical coherence tomography scanning is a valuable tool for showing important morphologic differences between CSC and AMD.
利用共焦光学相干断层扫描（OCT）对中心性浆液性脉络膜视网膜病变（CSC）和年龄相关性黄斑变性（AMD）的色素上皮脱离（PED）进行形态学差异评估。
我们招募了 22 例患者的 30 只眼，这些患者均有 PED。其中 9 只眼临床诊断为 CSC，21 只眼为 AMD。所有患者均接受共焦 OCT 评估。在 C 扫描上估计 PED 的形态方面，并根据形状、内轮廓、内容物、壁面、壁厚度和大小进行分类。
CSC 中 PED 形状主要为圆形（88.8%），AMD 中形状为不规则或多叶状（76.2%）。PED 的内轮廓在 CSC 中具有光滑的方面（88.9%），在 AMD 中具有轻微的颗粒状或颗粒状轮廓（100%）。清亮的 PED 内容物是 CSC 的最特征性特征（88.9%），但不是 AMD 的特征性特征。在 CSC 中，PED 形态壁面方面是均匀或稍不规则（100%），而在 AMD 中，壁面方面是稍不规则（52.4%）或不规则（47.6%）。AMD 中的 PED 壁厚度和尺寸大于 CSC。在 PED 内轮廓、内容物、壁面方面和壁厚度测量方面，CSC 和 AMD 之间存在统计学显著差异。
共焦 OCT 扫描是一种显示 CSC 和 AMD 之间重要形态学差异的有价值的工具。
