味精对慢性酒精中毒成年雄性小鼠动脉组织中各种脂质成分和某些抗氧化酶的影响。
Effect of monosodium glutamate on various lipid fractions and certain antioxidant enzymes in arterial tissue of chronic alcoholic adult male mice.
作者信息
Singh Kuldip, Kaur Jaspinder, Ahluwalia P, Sharma Jyoti
机构信息
Department of Biochemistry, Government Medical College, Amritsar -143001, India.
出版信息
Toxicol Int. 2012 Jan;19(1):9-14. doi: 10.4103/0971-6580.94507.
Abstract
Oral ingestion of monosodium glutamate (MSG) to chronic alcoholic adult male mice at dose levels of 4 and 8 mg/g body weight for seven consecutive days caused a significant increase in lipid fractions, lipid peroxidation, xanthine oxidase, whereas the levels of superoxide dismutase, catalase, glutathione, and its metabolizing enzymes like glutathione peroxidase and glutathione reductase were significantly decreased in the arterial tissue. These observations suggested that ingestion of MSG to chronic alcoholic animals had no beneficial effect and thereby, could act as an additional factor for the initiation of atherosclerosis.
摘要
对成年慢性酒精中毒雄性小鼠连续七天口服剂量为4和8毫克/克体重的味精（MSG），导致动脉组织中的脂质组分、脂质过氧化、黄嘌呤氧化酶显著增加，而超氧化物歧化酶、过氧化氢酶、谷胱甘肽及其代谢酶如谷胱甘肽过氧化物酶和谷胱甘肽还原酶的水平显著降低。这些观察结果表明，对慢性酒精中毒动物口服味精没有有益作用，因此，可能是引发动脉粥样硬化的一个额外因素。
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